Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.71 |
| ▸ | FLT4 | P35916 | 1/20 | 0.71 |
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | RARB | P10826 | 1/20 | 0.71 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | DPP4 | P27487 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322472 | 0.90 | KMT2A (0.72) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9149691 | 0.86 | KMT2A (0.86) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL14499425 | 0.85 | KMT2A (0.75) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL29383684 | 0.85 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL34354 | 0.85 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL34355 | 0.85 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL9323984 | 0.85 | KMT2A (1.00) | KMT2AEPHA2FLT4GSK3BRARB | |
| SCHEMBL9838625 | 0.85 | KMT2A (0.72) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL19149806 | 0.84 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB | |
| Tosufloxacin SCHEMBL3754459 | 0.84 | KMT2A (0.98) | KMT2AEPHA2FLT4GSK3BRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641339-B1 | AZASPIRO QUINOLONE ANTIBACTERIAL AGENTS | PFIZER (US) | 1999-09-15 | — | — | EP | claimed |
| US-5407943-A | Azaspiro quinolone antibacterial agents | PFIZER INC. (US) | 1995-04-18 | — | — | US | claimed |
| EP-0641339-B1 | AZASPIRO QUINOLONE ANTIBACTERIAL AGENTS | PFIZER (US) | 1999-09-15 | — | — | EP | disclosed |
| US-5407943-A | Azaspiro quinolone antibacterial agents | PFIZER INC. (US) | 1995-04-18 | — | — | US | disclosed |
| EP-0641339-A1 | AZASPIRO QUINOLONE ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1992022550-A1 | AZASPIRO QUINOLONE ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 1992-12-23 | — | — | WO | disclosed |