Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.70 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321908 | 0.89 | HDAC1 (0.70) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8325145 | 0.84 | GRIN1 (0.52) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL4631676 | 0.82 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL4631682 | 0.82 | HDAC1 (1.00) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8325113 | 0.82 | HDAC1 (0.70) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8326657 | 0.78 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL9540471 | 0.76 | GRIN2B (0.77) | GRIN1GRIN2B | |
| SCHEMBL8320552 | 0.75 | HDAC1 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8319323 | 0.75 | HDAC1 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8325016 | 0.75 | HDAC1 (0.73) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |