SCHEMBL8319285

SCHEMBL8319285

COCN1c2cc(Cn3ccnc3C(=O)c3ccc(C(=O)O)cc3)ccc2Sc2nccnc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 5/20 0.41
ICAM1 P05362 2/20 0.35
RAB9A P51151 2/20 0.34
NPC1 O15118 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
PKM P14618 1/20 0.33
CYP2C19 P33261 1/20 0.33
HDAC1 Q13547 3/20 0.32
HDAC3 O15379 2/20 0.32
MAPT P10636 1/20 0.32
POLB P06746 1/20 0.32
HDAC8 Q9BY41 2/20 0.31
HDAC4 P56524 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6750238 0.92 HDAC6 (0.42) HDAC6RAB9ANPC1SMN1; SMN2CYP1A2
SCHEMBL6745797 0.91 HDAC6 (0.41) HDAC6ICAM1RAB9ANPC1SMN1; SMN2
SCHEMBL6749757 0.85 HDAC6 (0.41) HDAC6RAB9ANPC1SMN1; SMN2PKM
SCHEMBL6747555 0.82 HDAC6 (0.44) HDAC6ICAM1MAPTPOLBALDH1A1
SCHEMBL6749035 0.80 HTT (0.44) HDAC6RAB9AMAPTALDH1A1
SCHEMBL6749379 0.79 HDAC6 (0.37) HDAC6
SCHEMBL8315505 0.79 HDAC6 (0.45) HDAC6SMN1; SMN2CYP1A2CYP3A4HDAC1
SCHEMBL8319484 0.79 HDAC6 (0.42) HDAC6ICAM1MAPTPOLB
SCHEMBL8319481 0.79 HDAC6 (0.42) HDAC6ICAM1MAPTPOLB
SCHEMBL6749755 0.79 HDAC6 (0.39) HDAC6HDAC1HDAC3MAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934941-A1 BENZOPIPERIDINE DERIVATIVES Eisai Co., Ltd. (JP) 1999-08-11 EP disclosed