Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327938 | 0.87 | HDAC1 (0.39) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8322776 | 0.84 | MGLL (0.40) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8323569 | 0.82 | MGLL (0.41) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8323071 | 0.81 | HSP90AA1 (0.42) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8323965 | 0.80 | HDAC1 (0.41) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8322800 | 0.79 | MGLL (0.41) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8325172 | 0.79 | HDAC1 (0.49) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL8319218 | 0.79 | HDAC1 (0.40) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8318949 | 0.79 | HDAC8 (0.37) | HDAC1KCNH2HDAC8HDAC6HDAC3 | |
| SCHEMBL8324625 | 0.79 | HDAC1 (0.55) | HDAC1KCNH2HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |