Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD44 | P16070 | 2/20 | 0.53 |
| ▸ | PNMT | P11086 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PRCP | P42785 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30519153 | 0.84 | P2RY1 (0.48) | CD44PNMTMAOBP2RY1 | |
| SCHEMBL25431215 | 0.84 | P2RY1 (0.48) | CD44PNMTMAOBP2RY1 | |
| Hydrochloric Acid SCHEMBL30519078 | 0.83 | P2RY1 (0.47) | CD44PNMTMAOBP2RY1 | |
| Hydrochloric Acid SCHEMBL25341340 | 0.83 | P2RY1 (0.47) | CD44PNMTMAOBP2RY1 | |
| SCHEMBL31233660 | 0.79 | PNMT (0.56) | CD44PNMTMAOBHTR2CHTR2B | |
| SCHEMBL2358135 | 0.79 | PNMT (0.56) | CD44PNMTMAOBHTR2CHTR2B | |
| Bromide SCHEMBL9719839 | 0.79 | CARM1 (0.44) | HTR2CHTR2BHTR1ASLC6A2SLC6A4 | |
| SCHEMBL5016341 | 0.78 | RXRB (0.48) | CD44HTR2CHTR2BHTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL33527957 | 0.78 | PNMT (0.55) | CD44PNMTMAOBHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1124611 | 0.78 | PNMT (0.55) | CD44PNMTMAOBHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687267-B1 | PYRROLO-PYRIDINE DERIVATIVES AS LIGANDS OF DOPAMINE RECEPTOR | MERCK SHARP & DOHME (GB) | 1999-09-01 | — | — | EP | disclosed |
| US-5700809-A | Pyrrolo-pyridine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1997-12-23 | — | — | US | disclosed |
| WO-1994020459-A2 | PYRROLO-PYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |