Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 8/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | SGK1 | O00141 | 5/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323355 | 0.81 | CAMKK2 (0.61) | AXLCDK8TNIKCAMKK2KIT | |
| SCHEMBL8321970 | 0.79 | CCNT1 (0.51) | CCNT1CCNA2CDK2CDK9AXL | |
| SCHEMBL12829496 | 0.74 | MAPK8 (0.64) | CCNT1CCNA2CDK2CDK9AXL | |
| SCHEMBL8321974 | 0.74 | PDPK1 (0.45) | AXLCDK8TNIKSGK1KIT | |
| SCHEMBL8321210 | 0.73 | CAMKK2 (0.70) | CCNT1CCNA2CDK2CDK9AXL | |
| SCHEMBL8317029 | 0.72 | MAPK8 (0.56) | AXLCDK8TNIKSGK1KIT | |
| SCHEMBL12829466 | 0.72 | MAPK8 (0.51) | AXLCDK8TNIKSGK1KIT | |
| SCHEMBL13745275 | 0.72 | CDK8 (0.67) | CCNT1CCNA2CDK2CDK9AXL | |
| SCHEMBL12763316 | 0.71 | DYRK1A (0.57) | CCNT1CCNA2CDK2CDK9AXL | |
| SCHEMBL12829517 | 0.70 | MAPK8 (0.52) | AXLCDK8TNIKSGK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |