Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 14/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 13/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 13/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385178 | 0.94 | GNAO1 (0.43) | GNAO1GNAI3GNAI1EPHX1 | |
| SCHEMBL9388207 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL9384209 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL9385199 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL9389327 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL9388852 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL9383352 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL9383347 | 0.92 | GNAO1 (0.46) | GNAO1GNAI3GNAI1EPHX1TSHR | |
| SCHEMBL2091402 | 0.89 | GNAO1 (0.35) | GNAO1GNAI3GNAI1EPHX1 | |
| SCHEMBL921716 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| EP-0812321-A1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026937-A1 | PROKINETIC OXADIAZOLES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-06 | — | — | WO | disclosed |
| EP-0604494-A1 | 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-06 | — | — | EP | disclosed |