Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 9/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318461 | 0.91 | EGFR (0.55) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8316917 | 0.90 | EGFR (0.71) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6990982 | 0.89 | EGFR (0.70) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998251 | 0.89 | EGFR (0.70) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317992 | 0.87 | EGFR (0.68) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8319394 | 0.86 | EGFR (0.50) | EGFRERBB2MAPTBRAF | |
| SCHEMBL8317479 | 0.85 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6993371 | 0.85 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8486032 | 0.85 | EGFR (0.65) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6993219 | 0.84 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |