Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 17/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320166 | 0.91 | EGFR (0.67) | EGFRERBB2MAPTBRAFHPGD | |
| SCHEMBL8315524 | 0.89 | EGFR (0.58) | EGFRERBB2MAPTBRAFHPGD | |
| SCHEMBL8319394 | 0.87 | EGFR (0.50) | EGFRERBB2MAPTBRAF | |
| SCHEMBL8316098 | 0.86 | ERBB2 (0.56) | EGFRERBB2MAPTBRAF | |
| SCHEMBL8314587 | 0.82 | EGFR (0.60) | EGFRBRAF | |
| SCHEMBL8315732 | 0.82 | EGFR (0.60) | EGFR | |
| SCHEMBL8312962 | 0.80 | EGFR (0.48) | EGFRERBB2MAPTBRAF | |
| SCHEMBL8316917 | 0.80 | EGFR (0.71) | EGFRERBB2MAPTBRAFHPGD | |
| SCHEMBL8318621 | 0.79 | ABCG2 (0.52) | EGFRBRAF | |
| SCHEMBL6998251 | 0.79 | EGFR (0.70) | EGFRERBB2MAPTBRAFHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |