Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17285888 | 0.95 | HTR2A (0.60) | HTR2AHTR2CKDM4EALDH1A1LTA4H | |
| SCHEMBL22878461 | 0.84 | HTR2A (0.48) | HTR2AHTR2CALDH1A1HRH3NPC1 | |
| SCHEMBL3569353 | 0.84 | HRH3 (0.69) | HRH3 | |
| SCHEMBL17284448 | 0.83 | HTR2A (0.47) | HTR2AHTR2CALDH1A1HRH3NPC1 | |
| SCHEMBL8251941 | 0.81 | HTR2A (0.58) | HTR2AHTR2CKDM4EALDH1A1LTA4H | |
| SCHEMBL17282051 | 0.81 | HTR2A (0.46) | HTR2AHTR2CALDH1A1HRH3NPC1 | |
| SCHEMBL17285945 | 0.80 | LTA4H (0.56) | HTR2AKDM4EALDH1A1LTA4HNOS2 | |
| SCHEMBL17286035 | 0.80 | HTR2A (0.56) | HTR2AKDM4EALDH1A1LTA4HNOS2 | |
| SCHEMBL13887902 | 0.78 | KDM4E (0.58) | HTR2AHTR2CKDM4EALDH1A1LTA4H | |
| SCHEMBL18412166 | 0.77 | KDM4E (0.57) | HTR2AHTR2CKDM4EALDH1A1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004066960-A2 | COMBINATION OF H1, H3 AND H4 RECEPTOR ANTAGONISTS FOR TREATMENT OF ALLERGIC AND NON-ALLERGIC PULMONARY INFLAMMATION, CONGESTION AND ALLERGIC RHINITIS | SCHERING CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |