Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1357542 | 0.85 | TSHR (0.47) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7771266 | 0.84 | LPAR6 (0.31) | LPAR1LPAR3 | |
| SCHEMBL19543524 | 0.83 | MEN1 (0.50) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL5502602 | 0.83 | TSHR (0.45) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL14644928 | 0.83 | TSHR (0.45) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL7776038 | 0.83 | TSHR (0.36) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL18251590 | 0.81 | MEN1 (0.55) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL6433059 | 0.81 | TSHR (0.43) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL18251591 | 0.81 | MEN1 (0.55) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL3673665 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |