Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.60 |
| ▸ | BACE1 | P56817 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PTGIR | P43119 | 1/20 | 0.56 |
| ▸ | CHKA | P35790 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320248 | 0.85 | HRH3 (0.69) | SIGMAR1SMN1; SMN2ACHEBACE1MEN1 | |
| SCHEMBL1043952 | 0.84 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2PTGIRCHKA | |
| SCHEMBL20804352 | 0.84 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2PTGIRCHKA | |
| SCHEMBL19285228 | 0.84 | SIGMAR1 (0.85) | SIGMAR1SMN1; SMN2PTGIRCHKA | |
| SCHEMBL8101249 | 0.83 | SIGMAR1 (0.63) | SIGMAR1SMN1; SMN2ACHEBACE1MEN1 | |
| SCHEMBL2390775 | 0.83 | MEN1 (0.68) | SIGMAR1SMN1; SMN2ACHEBACE1MEN1 | |
| SCHEMBL1586714 | 0.83 | SIGMAR1 (0.63) | SIGMAR1SMN1; SMN2ACHEBACE1MEN1 | |
| SCHEMBL10868711 | 0.83 | SIGMAR1 (0.63) | SIGMAR1SMN1; SMN2ACHEBACE1MEN1 | |
| Hydrochloric Acid SCHEMBL11534460 | 0.82 | SIGMAR1 (0.61) | SIGMAR1SMN1; SMN2ACHEBACE1MEN1 | |
| SCHEMBL22829113 | 0.81 | SIGMAR1 (0.68) | SIGMAR1ACHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484879-B1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2020-12-30 | — | — | EP | claimed |
| EP-3484879-B1 | HYDROXYQUINOLINONE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARM SPA (IT) | 2020-12-30 | — | — | EP | disclosed |
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | disclosed |
| CN-1040436-C | Pharmaceuticals | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | disclosed |
| CN-1073173-A | Preparation method as the compound of 5-hydroxytryptamine receptor antagonist | SMITHKLINE BEECHAM PLC (GB) | 1993-06-16 | — | — | CN | disclosed |