Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 8/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320277 | 1.00 | CSNK2A1 (0.56) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8317928 | 0.95 | EGFR (0.60) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8319108 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8319114 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8460531 | 0.88 | EGFR (0.58) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8316922 | 0.88 | EGFR (0.58) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8317438 | 0.88 | EGFR (0.66) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8316918 | 0.88 | EGFR (0.58) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8315969 | 0.88 | EGFR (0.66) | EGFRERBB2HPGDHTTBRAF | |
| SCHEMBL8322339 | 0.88 | EGFR (0.67) | EGFRERBB2HPGDHTTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |