Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | BCR | P11274 | 3/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14011223 | 0.91 | CDK4 (0.50) | EIF2AK2CAMK2DABL1PRKCAPRKCD | |
| SCHEMBL8324791 | 0.89 | EIF2AK2 (0.61) | EIF2AK2CAMK2DABL1BCRPRKCA | |
| SCHEMBL8320688 | 0.89 | PIK3CG (0.52) | EIF2AK2CAMK2DABL1BCRCDK2 | |
| SCHEMBL14011224 | 0.87 | SYK (0.51) | EIF2AK2ABL1BCRCDK2CDK4 | |
| SCHEMBL8320327 | 0.87 | JAK2 (0.45) | EIF2AK2ABL1BCRPRKCAPRKCD | |
| SCHEMBL8318589 | 0.86 | CDK4 (0.47) | EIF2AK2ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL8321435 | 0.85 | CDK2 (0.60) | EIF2AK2CYP1A2CYP2C19CDK2CDK4 | |
| SCHEMBL8316804 | 0.81 | CDK4 (0.59) | EIF2AK2CAMK2DALDH1A1CDK2CDK4 | |
| SCHEMBL8324564 | 0.79 | CDK4 (0.66) | EIF2AK2CDK2CDK4SYKKDR | |
| SCHEMBL2324173 | 0.79 | MAPT (0.61) | CAMK2DABL1BCRPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |