Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.66 |
| ▸ | CDK2 | P24941 | 10/20 | 0.66 |
| ▸ | EIF2AK2 | P19525 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324791 | 0.90 | EIF2AK2 (0.61) | CDK4CDK2EIF2AK2SYKKDM4E | |
| SCHEMBL8316804 | 0.89 | CDK4 (0.59) | CDK4CDK2EIF2AK2NPC1RAB9A | |
| SCHEMBL14011221 | 0.87 | SYK (0.53) | CDK4CDK2EIF2AK2SYKNPC1 | |
| SCHEMBL8326117 | 0.87 | CDK2 (0.51) | CDK4CDK2EIF2AK2KDRAURKB | |
| SCHEMBL8317365 | 0.83 | CDK2 (0.60) | CDK4CDK2EIF2AK2KDM4E | |
| SCHEMBL8317316 | 0.83 | CDK2 (0.74) | CDK4CDK2EIF2AK2KDM4ENPC1 | |
| SCHEMBL8325791 | 0.80 | CDK2 (0.56) | CDK4CDK2KDRPLK1KDM4E | |
| SCHEMBL14011222 | 0.80 | CDK2 (0.59) | CDK4CDK2 | |
| SCHEMBL14011223 | 0.80 | CDK4 (0.50) | CDK4CDK2EIF2AK2SYKSMN1; SMN2 | |
| SCHEMBL8320329 | 0.79 | EIF2AK2 (0.58) | CDK4CDK2EIF2AK2KDRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456190-B2 | Compositions useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2004083203-A1 | COMPOSITIONS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-09-30 | — | — | WO | disclosed |