Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CPT2 | P23786 | 1/20 | 0.45 |
| ▸ | CPT1A | P50416 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28323257 | 0.92 | SLC22A16 (0.56) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Acetic Acid SCHEMBL5670671 | 0.90 | SLC22A16 (0.54) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Bicarbonate SCHEMBL28323258 | 0.90 | MAPT (0.52) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Acetic Acid SCHEMBL11505402 | 0.88 | SLC22A16 (0.52) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Acetic Acid SCHEMBL31405638 | 0.88 | SLC22A16 (0.52) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Acetic Acid SCHEMBL11505398 | 0.88 | SLC22A16 (0.52) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Acetic Acid SCHEMBL28210362 | 0.87 | MAPT (0.50) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Carbamic Acid SCHEMBL11505013 | 0.86 | SLC22A16 (0.50) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Propionic Acid SCHEMBL11657756 | 0.86 | SLC22A16 (0.56) | SLC22A16MAPTCPT2CPT1ATSHR | |
| Carbamic Acid SCHEMBL11505008 | 0.86 | MAPT (0.50) | SLC22A16MAPTCPT2CPT1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5887653-A | USING QUATERNARY AMMONIUM COMPOUND | PLAINSMAN TECHNOLOGY, INC. (US) | 1999-03-30 | — | — | US | claimed |
| CN-105829375-B | Allophanate-isocyanurateing catalyst, polyisocyanate composition, method for producing the composition, and two-component coating composition | 东曹株式会社 | 2019-09-20 | — | — | CN | disclosed |
| CN-105829375-A | Allophanate-isocyanurateing catalyst, polyisocyanate composition, method for producing the composition, and two-component coating composition | 东曹株式会社 | 2016-08-03 | — | — | CN | disclosed |
| US-5887653-A | USING QUATERNARY AMMONIUM COMPOUND | PLAINSMAN TECHNOLOGY, INC. (US) | 1999-03-30 | — | — | US | disclosed |