Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 2/20 | 0.37 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 4/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531034 | 0.94 | ADORA1 (0.43) | ADORA1FABP3FABP4S1PR5 | |
| SCHEMBL7521598 | 0.89 | ADORA1 (0.45) | ADORA1ALDH1A1CASP1SMN1; SMN2KDM4E | |
| SCHEMBL7518668 | 0.85 | ADORA1 (0.41) | ADORA1ALDH1A1FBP1 | |
| SCHEMBL7520497 | 0.79 | ADORA1 (0.40) | ADORA1LMNAFABP3FABP4S1PR5 | |
| SCHEMBL7526025 | 0.79 | KDM4E (0.42) | ADORA1ALDH1A1CASP1SMN1; SMN2KDM4E | |
| SCHEMBL7974210 | 0.77 | ADORA1 (0.41) | ADORA1LMNAFABP4TP53SMN1; SMN2 | |
| SCHEMBL7518636 | 0.77 | ALDH1A1 (0.41) | ADORA1LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL7522397 | 0.77 | ADORA1 (0.38) | ADORA1LMNAFABP3FABP4ALDH1A1 | |
| SCHEMBL7526545 | 0.75 | ADORA1 (0.38) | ADORA1FABP3FABP4S1PR5ALDH1A1 | |
| SCHEMBL7528838 | 0.74 | ADORA1 (0.39) | ADORA1FABP3FABP4S1PR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929534-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | Takeda Pharmaceutical Company Limited (JP) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013356-A1 | TRYCYCLIC COMPOUNDS AS PROSTAGLANDIN I2 RECEPTOR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-02 | — | — | WO | disclosed |