Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.56 |
| ▸ | PDE4A | P27815 | 19/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1143518 | 0.86 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| Hydrochloric Acid SCHEMBL1144045 | 0.85 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL27735649 | 0.78 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL28628502 | 0.77 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL832576 | 0.77 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL16411001 | 0.77 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL23717240 | 0.76 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL6461060 | 0.76 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL29723540 | 0.76 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4DABCB11 | |
| SCHEMBL16409548 | 0.76 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587474-B1 | FLUOROALKOXY-SUBSTITUTED 1, 3-DIHYDRO-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES | CELGENE CORP (US) | 2009-11-18 | — | — | EP | disclosed |
| US-7504427-B2 | Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses | CELGENE CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |
| WO-2004060313-A2 | FLUOROALKOXY-SUBSTITUTED 1, 3-DIHYDRO-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES | CELGENE CORPORATION (US) | 2004-07-22 | — | — | WO | disclosed |