Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetramethrin SCHEMBL22714265 | 0.79 | LMNA (0.56) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| Tetramethrin SCHEMBL7926801 | 0.79 | LMNA (0.56) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| Tetramethrin SCHEMBL27009 | 0.79 | LMNA (0.56) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| (1R)-Trans-Tetramethrin SCHEMBL2973441 | 0.79 | LMNA (0.56) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| Tetramethrin SCHEMBL5883725 | 0.78 | LMNA (0.52) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| Tetramethrin SCHEMBL28849516 | 0.75 | LMNA (0.53) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL9717311 | 0.75 | LMNA (0.61) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL5550777 | 0.74 | LMNA (0.45) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1234452 | 0.74 | LMNA (0.47) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 | |
| Chrysanthemic Acid, Ethyl Ester SCHEMBL3676624 | 0.72 | LMNA (1.00) | LMNACYP1A2CYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004066987-A2 | USE OF SODIUM CHANNEL MODULATORS FOR TREATING GASTROINTESTINAL TRACT DISORDERS | DYNOGEN PHARMACEUTICALS, INC. (US) | 2004-08-12 | — | — | WO | disclosed |
| WO-2004066990-A2 | METHODS OF TREATING LOWER URINARY TRACT DISORDERS USING SODIUM CHANNEL MODULATORS | DYNOGEN PHARMACEUTICALS, INC. (US) | 2004-08-12 | — | — | WO | disclosed |