Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 6/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL832909 | 0.87 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DBLM | |
| SCHEMBL829469 | 0.87 | MKNK2 (0.40) | GABRA1GABRA5PDE4APDE4BPDE4C | |
| SCHEMBL832928 | 0.86 | MAPT (0.44) | PDE4APDE4BPDE4CPDE4DBLM | |
| SCHEMBL831838 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DBLM | |
| SCHEMBL829212 | 0.86 | GABRA1 (0.42) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL832108 | 0.81 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DBLM | |
| SCHEMBL12624448 | 0.78 | PTGDR2 (0.43) | PDE4APDE4BPDE4CPDE4DBLM | |
| SCHEMBL832301 | 0.77 | PTGDR2 (0.42) | PDE4APDE4BPDE4CPDE4DBLM | |
| SCHEMBL830781 | 0.75 | GABRA1 (0.55) | GABRA1GABRA5NPSR1CYP2C19GABRG2 | |
| SCHEMBL12655601 | 0.74 | MKNK2 (0.42) | PDE4APDE4BPDE4CPDE4DBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110104109-A1 | TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-05-05 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110104109-A1 | TETRACYCLIC INDOLE DERIVATIVES AND THEIR USE FOR TREATING OR PREVENTING VIRAL INFECTIONS | IDO1, IDO2, ZC3HAV1 | GABRA1 2809/4885GABRA5 2096/4885PDE4A 3725/4885 |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | GABRA1 4029/4885GABRA5 3618/4885PDE4A 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.