Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HRH1 | P35367 | 4/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11127650 | 0.84 | POLB (0.40) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| Water SCHEMBL11427319 | 0.84 | POLB (0.40) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| SCHEMBL11307941 | 0.81 | POLB (0.40) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| SCHEMBL28686414 | 0.79 | POLB (0.39) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| SCHEMBL11303207 | 0.79 | POLB (0.39) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| Water SCHEMBL11433511 | 0.79 | POLB (0.39) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL11129021 | 0.79 | POLB (0.39) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| SCHEMBL9147002 | 0.79 | HTR2A (0.44) | HTR2ACSNK1ESIGMAR1 | |
| SCHEMBL8536105 | 0.79 | POLB (0.41) | POLBKDM4EALDH1A1HTR2AHRH1 | |
| SCHEMBL8536103 | 0.79 | POLB (0.41) | POLBKDM4EALDH1A1HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |