Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322616 | 0.89 | ABCB1 (0.52) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8328278 | 0.89 | SMPD1 (0.56) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8323831 | 0.87 | PTGER1 (0.52) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8324369 | 0.87 | PTGER1 (0.52) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8406671 | 0.85 | HTR1A (0.66) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8324233 | 0.85 | PTGER4 (0.61) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8318749 | 0.84 | BRD4 (0.57) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL8322427 | 0.84 | PTGER1 (0.49) | LMNAHPGDPTGER1PTGER4PTGER3 | |
| SCHEMBL1782909 | 0.83 | HPGD (0.72) | LMNAHPGDL3MBTL1MAPTRAB9A | |
| SCHEMBL8408175 | 0.83 | HPGD (0.56) | LMNAHPGDPTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |