Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321429 | 0.95 | SOAT1 (0.35) | SOAT1GPR84 | |
| SCHEMBL8324413 | 0.95 | SOAT1 (0.35) | SOAT1GPR84 | |
| SCHEMBL8319647 | 0.95 | SOAT1 (0.35) | SOAT1GPR84 | |
| SCHEMBL8325251 | 0.88 | SOAT1 (0.34) | SOAT1GPR84 | |
| SCHEMBL8323636 | 0.84 | SOAT1 (0.38) | SOAT1LMNA | |
| SCHEMBL8322821 | 0.83 | — | — | |
| SCHEMBL9225520 | 0.82 | SOAT1 (0.38) | SOAT1 | |
| SCHEMBL9225723 | 0.79 | SOAT1 (0.38) | SOAT1GPR84 | |
| SCHEMBL8323297 | 0.78 | LMNA (0.31) | LMNA | |
| SCHEMBL8323237 | 0.78 | LMNA (0.31) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609960-B1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |