Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928892 | 0.80 | KDM4E (0.49) | KDM4EHPGDALDH1A1LMNATP53 | |
| SCHEMBL18717627 | 0.78 | KDM4E (0.75) | KDM4EHPGDALDH1A1LMNATP53 | |
| SCHEMBL12057234 | 0.75 | MEN1 (0.49) | KDM4EHPGDALDH1A1TSHRHSD17B10 | |
| SCHEMBL18694045 | 0.66 | HPGD (0.64) | KDM4EHPGDALDH1A1LMNATP53 | |
| SCHEMBL18509051 | 0.65 | MEN1 (0.38) | KDM4EHPGDALDH1A1LMNATSHR | |
| SCHEMBL18694592 | 0.64 | HPGD (0.61) | KDM4EHPGDALDH1A1LMNATP53 | |
| SCHEMBL30667957 | 0.61 | S1PR2 (0.44) | KDM4EHPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL22805433 | 0.61 | S1PR2 (0.44) | KDM4EHPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL18694583 | 0.61 | KDM4E (0.60) | KDM4EHPGDALDH1A1LMNATP53 | |
| SCHEMBL2250305 | 0.60 | CCNE2 (0.39) | CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765327-B1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER (US) | 1999-07-21 | — | — | EP | disclosed |