Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937098 | 0.80 | CRHR1 (0.46) | KDM4EHPGDALDH1A1CRHR1CDK4 | |
| SCHEMBL8122423 | 0.80 | CRHR1 (0.55) | KDM4EHPGDALDH1A1CRHR1CDK4 | |
| SCHEMBL8323206 | 0.80 | KDM4E (0.50) | KDM4EHPGDALDH1A1CRHR1CDK4 | |
| SCHEMBL7937119 | 0.78 | CRHR1 (0.46) | KDM4EHPGDALDH1A1CRHR1CDK4 | |
| SCHEMBL18717627 | 0.77 | KDM4E (0.75) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL7935053 | 0.76 | ALDH1A1 (0.50) | KDM4EHPGDALDH1A1CRHR1CDK4 | |
| SCHEMBL7935049 | 0.74 | CRHR1 (0.47) | CRHR1LMNAMAPTTDP1L3MBTL1 | |
| SCHEMBL7619917 | 0.74 | CRHR1 (0.44) | KDM4EHPGDALDH1A1CRHR1LMNA | |
| SCHEMBL12057234 | 0.74 | MEN1 (0.49) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL7961654 | 0.73 | CRHR1 (0.54) | KDM4EHPGDALDH1A1CRHR1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248753-B1 | CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONISTS | PFIZER INC | 2001-06-19 | — | — | US | disclosed |
| EP-0765327-B1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0765327-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034563-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1995-12-21 | — | — | WO | disclosed |