Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | HMGCR | P04035 | 5/20 | 0.54 |
| ▸ | RXRA | P19793 | 3/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323630 | 0.93 | NR4A2 (0.68) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8320769 | 0.92 | PDE4D (0.75) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8321515 | 0.89 | PDE4D (0.69) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8323698 | 0.88 | PDE4D (0.65) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8327007 | 0.86 | HMGCR (0.56) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8318443 | 0.86 | NR4A2 (0.83) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8318209 | 0.85 | NR4A2 (0.71) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8321759 | 0.84 | PDE4D (0.78) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8319301 | 0.82 | PDE4D (0.75) | PDE4DNR4A2NR1I2HMGCRRXRA | |
| SCHEMBL8323363 | 0.80 | NR4A2 (0.71) | PDE4DNR4A2NR1I2HMGCRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304063-B1 | Quinoline type mevalonolactones | NISSAN CHEMICAL IND LTD (JP) | 1994-11-30 | — | — | EP | claimed |
| EP-0304063-A2 | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-02-22 | — | — | EP | claimed |
| US-5872130-A | ANTI-HYPERLIPIDEMIC, HYPOLIPOPROTEINEMIC AND ANTI-ATHEROSCLEROTIC AGENTS | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| US-5856336-A | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1999-01-05 | — | — | US | disclosed |
| US-5854259-A | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1998-12-29 | — | — | US | disclosed |
| EP-0304063-B1 | Quinoline type mevalonolactones | NISSAN CHEMICAL IND LTD (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-5185328-A | Hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| US-5102888-A | QUINOLINE TYPE MEVALONOLACTONES USEFUL FOR TREATING HYPERLIPIDEMIA AND RELATED DISEASES | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5011930-A | Antilipemic agents, anticoagulants | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-04-30 | — | — | US | disclosed |
| EP-0304063-A2 | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-02-22 | — | — | EP | disclosed |