Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PDE6D | O43924 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.39 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318634 | 0.92 | HMGCR (0.56) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8323040 | 0.92 | HMGCR (0.68) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8323700 | 0.89 | HMGCR (0.56) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8318211 | 0.87 | HMGCR (0.54) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8323292 | 0.86 | PDE4D (0.62) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8325578 | 0.86 | PDE4D (0.59) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8318309 | 0.85 | FABP3 (0.55) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL10661593 | 0.84 | HMGCR (0.65) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL8321007 | 0.84 | HMGCR (0.65) | HMGCRTBXA2RADRA1AESR1CHRM1 | |
| SCHEMBL10661824 | 0.84 | HMGCR (0.65) | HMGCRTBXA2RADRA1AESR1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304063-B1 | Quinoline type mevalonolactones | NISSAN CHEMICAL IND LTD (JP) | 1994-11-30 | — | — | EP | claimed |
| EP-0304063-A2 | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-02-22 | — | — | EP | claimed |
| US-5872130-A | ANTI-HYPERLIPIDEMIC, HYPOLIPOPROTEINEMIC AND ANTI-ATHEROSCLEROTIC AGENTS | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| US-5856336-A | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1999-01-05 | — | — | US | disclosed |
| US-5854259-A | Quinoline type mevalonolactones | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1998-12-29 | — | — | US | disclosed |
| EP-0304063-B1 | Quinoline type mevalonolactones | NISSAN CHEMICAL IND LTD (JP) | 1994-11-30 | — | — | EP | disclosed |
| US-5185328-A | Hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1993-02-09 | — | — | US | disclosed |
| US-5102888-A | QUINOLINE TYPE MEVALONOLACTONES USEFUL FOR TREATING HYPERLIPIDEMIA AND RELATED DISEASES | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5011930-A | Antilipemic agents, anticoagulants | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1991-04-30 | — | — | US | disclosed |