Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | ACP3 | P15309 | 3/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941221 | 0.81 | PBRM1 (0.62) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL8429413 | 0.81 | PBRM1 (0.62) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL8323074 | 0.80 | PBRM1 (0.54) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL2123177 | 0.79 | ACP3 (0.58) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL8324974 | 0.79 | KMT2A (0.40) | ALDH1A1PKMMAPTNPC1NPSR1 | |
| SCHEMBL25791341 | 0.78 | TDP1 (0.54) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL13184504 | 0.78 | TDP1 (0.54) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL13164290 | 0.76 | CA4 (0.58) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| SCHEMBL682837 | 0.76 | CA4 (0.58) | PBRM1ALDH1A1ACP3CA4LTA4H | |
| Hydrochloric Acid SCHEMBL20524446 | 0.74 | ACP3 (0.46) | PBRM1ALDH1A1ACP3TDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |