Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328722 | 0.84 | IDO1 (0.42) | SLC6A4SLC6A2KDM4ECNR2 | |
| SCHEMBL8327275 | 0.79 | SLC6A4 (0.51) | KMT2AMEN1SLC6A4NPC1SLC6A2 | |
| SCHEMBL8323402 | 0.79 | PBRM1 (0.50) | KMT2AMEN1NPC1ALDH1A1CYP3A4 | |
| SCHEMBL8326598 | 0.79 | NPC1 (0.42) | KMT2AMEN1SLC6A4NPC1ALDH1A1 | |
| SCHEMBL23209633 | 0.76 | ALDH1A1 (0.46) | KMT2AMEN1SLC6A4NPC1SLC6A2 | |
| SCHEMBL27669927 | 0.75 | LMNA (0.43) | NPC1ALDH1A1LMNAHTTNPSR1 | |
| SCHEMBL2122133 | 0.75 | LMNA (0.43) | NPC1ALDH1A1LMNAHTTNPSR1 | |
| SCHEMBL8325683 | 0.75 | CYP3A4 (0.38) | KMT2AMEN1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL17069292 | 0.74 | NPC1 (0.44) | KMT2AMEN1SLC6A4NPC1ALDH1A1 | |
| SCHEMBL17069287 | 0.74 | NPC1 (0.44) | KMT2AMEN1SLC6A4NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |