SCHEMBL8323443

SCHEMBL8323443

COc1ccc2c(c1)CCNC2=O.COc1ccc2c(c1)CCNC2=O

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 5/20 0.67
PARP10 Q53GL7 9/20 0.63
PARP11 Q9NR21 9/20 0.63
RYR2 Q92736 1/20 0.54
PARP1 P09874 2/20 0.51
PDPK1 O15530 1/20 0.51
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
MTNR1A P48039 1/20 0.50
MTNR1B P49286 1/20 0.50
MAPKAPK2 P49137 1/20 0.49
METAP1 P53582 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL379341 1.00 GRM5 (0.67) GRM5PARP10PARP11RYR2PARP1
SCHEMBL3692167 0.90 GRM5 (0.56) GRM5PARP10PARP11RYR2PARP1
SCHEMBL8161680 0.88 PARP11 (0.68) GRM5PARP10PARP11PARP1PDPK1
SCHEMBL29438649 0.87 PARP10 (0.63) GRM5PARP10PARP11RYR2PARP1
SCHEMBL246378 0.87 PARP10 (0.63) GRM5PARP10PARP11RYR2PARP1
SCHEMBL12230826 0.86 PARP10 (0.56) GRM5PARP10PARP11RYR2PARP1
SCHEMBL8154135 0.84 PARP10 (0.69) GRM5PARP10PARP11PARP1PDPK1
SCHEMBL504342 0.84 GRM5 (0.79) GRM5PARP10PARP11MAPKAPK2
SCHEMBL12077584 0.84 RYR2 (0.51) GRM5PARP10PARP11RYR2KDM4E
SCHEMBL21040262 0.83 PARP11 (0.55) GRM5PARP10PARP11PARP1PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0869787-A4 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1999-03-24 EP disclosed
EP-0869787-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1998-10-14 EP disclosed
WO-1997024119-A1 VITRONECTIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-07-10 WO disclosed