Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.54 |
| ▸ | SGK1 | O00141 | 3/20 | 0.52 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | IL2 | P60568 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14049334 | 0.90 | MAP3K11 (0.56) | MAP3K11MAP4K1SGK1CAMKK2MAPK8 | |
| SCHEMBL8322765 | 0.84 | MAP3K11 (0.63) | MAP3K11SGK1CAMKK2MAPK8MAPK9 | |
| SCHEMBL12829937 | 0.84 | MAP3K11 (0.63) | MAP3K11SGK1CAMKK2MAPK8MAPK9 | |
| SCHEMBL12829944 | 0.81 | NTRK1 (0.61) | MAP3K11MAP4K1SGK1CAMKK2KIT | |
| SCHEMBL21592829 | 0.78 | MAP4K1 (0.56) | KMT2AMAP3K11MAP4K1KITIL2 | |
| SCHEMBL21592687 | 0.78 | KIT (0.62) | MAP3K11MAP4K1KITIL2TNIK | |
| SCHEMBL8313408 | 0.78 | MAP3K11 (0.58) | POLBMAP3K11SGK1CAMKK2KIT | |
| SCHEMBL13745551 | 0.78 | CDK8 (0.48) | MEN1KMT2APOLBMAP4K1CAMKK2 | |
| SCHEMBL13342353 | 0.77 | MAP4K1 (0.55) | MAP3K11MAP4K1SGK1CAMKK2KIT | |
| SCHEMBL13342356 | 0.76 | ABL1 (0.57) | MAP3K11MAP4K1SGK1CAMKK2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295433-A2 | JNK inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2011-03-16 | — | — | EP | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | MEN1 4830/4885KMT2A 3339/4885POLB 2249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.