Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.81 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.81 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.81 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.81 |
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | PPIA | P62937 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319420 | 0.89 | PTGER1 (1.00) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8321768 | 0.86 | PTGER1 (0.95) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8324836 | 0.85 | PTGER1 (0.92) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL4001433 | 0.85 | PARP1 (0.65) | PTGER1PTGER4PTGER3PTGER2PARP1 | |
| SCHEMBL8321384 | 0.85 | PTGER1 (0.77) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8322717 | 0.85 | PTGER1 (0.77) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL9057460 | 0.84 | HTR1A (0.79) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL8674686 | 0.84 | PTGER1 (0.64) | PTGER1PTGER4PTGER3PTGER2PARP1 | |
| SCHEMBL8322772 | 0.83 | PTGER1 (0.73) | PTGER1PTGER4PTGER3PTGER2HTR1A | |
| SCHEMBL9064386 | 0.83 | PTGER1 (0.73) | PTGER1PTGER4PTGER3PTGER2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |