Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.57 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.57 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323838 | 1.00 | PTGER1 (0.57) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8322341 | 0.89 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8319700 | 0.89 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8319694 | 0.89 | PTGER4 (0.53) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8321350 | 0.86 | PTGER4 (0.55) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8325293 | 0.86 | PTGER4 (0.55) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8321345 | 0.86 | PTGER4 (0.55) | PTGER1PTGER4PTGER3PTGER2CCNB2 | |
| SCHEMBL8323393 | 0.85 | GCK (0.62) | PTGER1PTGER4PTGER3PTGER2PTPN1 | |
| SCHEMBL8323389 | 0.85 | GCK (0.62) | PTGER1PTGER4PTGER3PTGER2PTPN1 | |
| SCHEMBL7774919 | 0.81 | PTGER1 (0.64) | PTGER1PTGER4PTGER3PTGER2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |