Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 5/20 | 0.31 |
| ▸ | PPARG | P37231 | 4/20 | 0.31 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322817 | 0.90 | PPARA (0.32) | SPHK1PPARAPPARGPTGESPPARD | |
| SCHEMBL8322453 | 0.89 | EPHX1 (0.34) | SPHK1PPARAPPARG | |
| SCHEMBL8327680 | 0.89 | EPHX1 (0.34) | SPHK1PPARAPPARG | |
| SCHEMBL8323242 | 0.89 | EPHX1 (0.34) | SPHK1PPARAPPARG | |
| SCHEMBL8320377 | 0.87 | HDAC8 (0.38) | — | |
| SCHEMBL8325248 | 0.83 | SOAT1 (0.37) | PPARAPPARGPTGESPPARDGPR84 | |
| SCHEMBL8323342 | 0.79 | LMNA (0.34) | PPARAPPARGPTGESALOX5 | |
| SCHEMBL8319274 | 0.78 | LMNA (0.34) | PPARAMMP9MMP13ADAM17GPR84 | |
| SCHEMBL8323141 | 0.77 | CETP (0.43) | SPHK1 | |
| SCHEMBL8324408 | 0.77 | CETP (0.43) | SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609960-B1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |