Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275345 | 0.82 | ALDH1A1 (0.44) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL18894008 | 0.82 | GAA (0.40) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL12812535 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL9077016 | 0.78 | ALDH1A1 (0.41) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL11118607 | 0.77 | GAA (0.42) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL27946223 | 0.76 | SLC1A3 (0.43) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL8570960 | 0.75 | CHRM2 (0.45) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL13281142 | 0.74 | GAA (0.40) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL8570516 | 0.73 | GAA (0.41) | ALDH1A1GAAKMT2AMEN1MAPT | |
| SCHEMBL8569587 | 0.73 | GAA (0.41) | ALDH1A1GAAKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592684-B1 | MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |
| WO-2004069826-A1 | MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | disclosed |