SCHEMBL8324039

SCHEMBL8324039

COC(=O)CCc1c(C(=O)OC)[nH]c2c(C)ccc(C)c12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.52
HPGD P15428 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.45
TDP1 Q9NUW8 1/20 0.44
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C19 P33261 1/20 0.43
TSHR P16473 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
CYP2C9 P11712 1/20 0.43
GAA P10253 1/20 0.43
ALOX12 P18054 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
EGFR P00533 1/20 0.40
SRC P12931 1/20 0.40
PDE3B Q13370 1/20 0.40
PDE3A Q14432 1/20 0.40
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8322259 0.83 CYP1A2 (0.48) MAPK1HPGDTDP1CYP1A2CYP3A4
SCHEMBL8323191 0.82 CYP1A2 (0.47) MAPK1HPGDTDP1CYP1A2CYP3A4
SCHEMBL8324009 0.78 CYP1A2 (0.43) MAPK1HPGDSMN1; SMN2CYP1A2CYP3A4
SCHEMBL8318646 0.78 CYP1A2 (0.43) MAPK1HPGDCYP1A2CYP3A4CYP2C19
SCHEMBL8323510 0.76 HPGD (0.39) MAPK1HPGDSMN1; SMN2CYP1A2CYP3A4
SCHEMBL8318534 0.75 KDM4E (0.46) HPGDSMN1; SMN2TDP1CYP1A2CYP3A4
SCHEMBL8324480 0.75 NR4A2 (0.41) CYP1A2CYP3A4CYP2C19TSHRKMT2A
SCHEMBL8324886 0.74 CYP1A2 (0.40) HPGDSMN1; SMN2TDP1CYP1A2CYP3A4
SCHEMBL8326080 0.74 CYP1A2 (0.40) HPGDTDP1CYP1A2CYP3A4CYP2C19
SCHEMBL8321899 0.74 CYP1A2 (0.40) HPGDTDP1CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5866594-A Indole-2-carboxylate derivatives and fungicidal compositions for agricultural or horticultural use containing the derivatives as active component OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1999-02-02 US disclosed
EP-0791582-A1 INDOLE-2-CARBOXYLIC ESTER DERIVATIVES AND AGRICULTURAL AND HORTICULTURAL BACTERIOCIDES CONTAINING THE SAME AS THE ACTIVE INGREDIENT OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1997-08-27 EP disclosed