Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | FOS | P01100 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.49 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19244362 | 0.86 | KDM4E (0.74) | KDM4EALDH1A1SMN1; SMN2PKMFOS | |
| SCHEMBL19244360 | 0.86 | KDM4E (0.74) | KDM4EALDH1A1SMN1; SMN2PKMFOS | |
| SCHEMBL29971843 | 0.84 | ALDH1A1 (0.76) | KDM4EALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL12617015 | 0.84 | ALDH1A1 (0.76) | KDM4EALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL12617165 | 0.84 | ALDH1A1 (0.76) | KDM4EALDH1A1SMN1; SMN2LMNAPKM | |
| SCHEMBL11681784 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2PKMHTT | |
| SCHEMBL11681779 | 0.83 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2PKMHTT | |
| SCHEMBL19244235 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2PKMFOS | |
| SCHEMBL8322532 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2PKMHTT | |
| SCHEMBL8325199 | 0.82 | CA12 (0.58) | KDM4EALDH1A1LMNAHTTPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |