Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.80 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.80 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.80 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.80 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8408169 | 0.92 | PTGER1 (0.67) | PTGER1PTGER4PTGER3PTGER2PDE4A | |
| SCHEMBL8319420 | 0.89 | PTGER1 (1.00) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8321768 | 0.86 | PTGER1 (0.95) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8324836 | 0.85 | PTGER1 (0.92) | PTGER1PTGER4PTGER3PTGER2PLA2G4B | |
| SCHEMBL8675522 | 0.84 | PTGER1 (0.58) | PTGER1PTGER4PTGER3PTGER2PTGES | |
| SCHEMBL6260223 | 0.81 | PTGER4 (0.67) | PTGER1PTGER4PTGER3PTGER2PLA2G4B | |
| SCHEMBL8327698 | 0.80 | PTGER1 (0.78) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL9056821 | 0.80 | PTGER1 (0.78) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8319795 | 0.80 | PTGER1 (0.78) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL15726355 | 0.80 | PTGER1 (0.84) | PTGER1PTGER4PTGER3PTGER2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |