Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402801 | 0.81 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL149582 | 0.81 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL7378695 | 0.81 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL7378697 | 0.81 | CYP1A2 (0.63) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL9475914 | 0.80 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL9475919 | 0.80 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL9477455 | 0.79 | CA1 (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL9477461 | 0.79 | CA1 (0.52) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL7274765 | 0.78 | NFKB1 (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL7316254 | 0.78 | NFKB1 (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866708-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0866708-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997017969-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-05-22 | — | — | WO | disclosed |