SCHEMBL8324465

SCHEMBL8324465

CN1CC[C@H]2CCCCC2C1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
NCF1 P14598 1/20 0.37
GNAI3 P08754 1/20 0.36
GNAO1 P09471 1/20 0.36
GNAI1 P63096 1/20 0.36
SLC18A3 Q16572 2/20 0.35
HRH3 Q9Y5N1 5/20 0.35
SIGMAR1 Q99720 3/20 0.35
HSD11B1 P28845 1/20 0.35
HTR1A P08908 1/20 0.33
HTR7 P34969 1/20 0.33
HRH1 P35367 1/20 0.33
DRD3 P35462 1/20 0.33
HTR2B P41595 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1776518 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL14589323 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL255094 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL14640696 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL443188 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL12440194 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL254415 1.00 ALDH1A1 (0.42) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL13162976 0.97 ALDH1A1 (0.40) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL21238903 0.97 ALDH1A1 (0.40) ALDH1A1NCF1GNAI3GNAO1GNAI1
SCHEMBL22591830 0.97 ALDH1A1 (0.40) ALDH1A1NCF1GNAI3GNAO1GNAI1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3305789-A1 NITROGEN-CONTAINING TRICYCLIC DERIVATIVE HAVING HIV REPLICATION INHIBITORY ACTIVITY Shionogi & Co., Ltd. (JP) 2018-04-11 EP disclosed
US-7528140-B2 Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors TEIJIN LIMITED (JP) 2009-05-05 US disclosed
EP-1592684-B1 MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS HOFFMANN LA ROCHE (CH) 2008-07-30 EP disclosed
WO-2004069826-A1 MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-08-19 WO disclosed