Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.59 |
| ▸ | HTR2A | P28223 | 12/20 | 0.59 |
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | DRD5 | P21918 | 2/20 | 0.59 |
| ▸ | HTR1D | P28221 | 2/20 | 0.59 |
| ▸ | HTR1B | P28222 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328526 | 0.90 | DRD2 (0.66) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| SCHEMBL8327642 | 0.89 | DRD2 (0.59) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| SCHEMBL8319486 | 0.89 | DRD2 (0.59) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| SCHEMBL8070959 | 0.89 | DRD2 (0.59) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| Ocaperidone SCHEMBL122321 | 0.87 | DRD2 (0.66) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| Ocaperidone SCHEMBL29710913 | 0.87 | DRD2 (0.66) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| SCHEMBL1430466 | 0.86 | DRD2 (0.65) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| SCHEMBL7299513 | 0.85 | DRD2 (0.65) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| SCHEMBL7298917 | 0.85 | DRD2 (0.63) | DRD2HTR2AHTR1AHRH3KCNH2 | |
| Ocaperidone SCHEMBL4590272 | 0.84 | DRD2 (0.59) | DRD2HTR2AHTR1AHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730594-B1 | 9-HYDROXY-PYRIDO [1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1999-09-08 | — | — | EP | disclosed |
| EP-0730594-A1 | NOVEL 9-HYDROXY-PYRIDO [1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014691-A1 | NOVEL 9-HYDROXY-PYRIDO[1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-06-01 | — | — | WO | disclosed |