Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.67 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.67 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.67 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.67 |
| ▸ | RXRA | P19793 | 5/20 | 0.48 |
| ▸ | RXRB | P28702 | 4/20 | 0.48 |
| ▸ | RXRG | P48443 | 3/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324492 | 1.00 | PTGER1 (0.67) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8408271 | 0.93 | PTGER1 (0.57) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8408269 | 0.93 | PTGER1 (0.57) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8322870 | 0.91 | PTGER1 (0.55) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8318002 | 0.89 | PTGER1 (0.73) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8676020 | 0.88 | PTGER1 (0.54) | PTGER1PTGER4PTGER3PTGER2MTNR1B | |
| SCHEMBL8323764 | 0.87 | PTGER1 (0.67) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8324840 | 0.87 | PTGER1 (0.67) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8324053 | 0.87 | PTGER1 (0.61) | PTGER1PTGER4PTGER3PTGER2RXRA | |
| SCHEMBL8326520 | 0.86 | MTNR1B (0.56) | PTGER1PTGER4PTGER3PTGER2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | claimed |
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |