Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.47 |
| ▸ | EDNRB | P24530 | 15/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323785 | 0.94 | EDNRA (0.51) | EDNRAEDNRBLMNA | |
| SCHEMBL8327010 | 0.93 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8323818 | 0.92 | EDNRA (0.48) | EDNRAEDNRBEPHA2KDREPHB4 | |
| SCHEMBL8323019 | 0.92 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8323894 | 0.88 | EDNRA (0.47) | EDNRAEDNRBEPHA2KDREPHB4 | |
| SCHEMBL8323252 | 0.88 | EDNRA (0.59) | EDNRAEDNRBEPHA2KDREPHB4 | |
| SCHEMBL8327017 | 0.87 | EDNRA (0.55) | EDNRAEDNRBLMNA | |
| SCHEMBL8327899 | 0.85 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL8326887 | 0.85 | EDNRA (0.52) | EDNRAEDNRB | |
| SCHEMBL8323904 | 0.84 | EDNRA (0.47) | EDNRAEDNRBEPHA2KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | claimed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |