Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.59 |
| ▸ | EDNRB | P24530 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320816 | 0.93 | EDNRA (0.64) | EDNRAEDNRBLMNAEPHA2KDR | |
| SCHEMBL8322054 | 0.90 | EDNRA (0.57) | EDNRAEDNRBLMNAEPHA2KDR | |
| SCHEMBL8324487 | 0.90 | EDNRA (0.61) | EDNRAEDNRBLMNA | |
| SCHEMBL8327574 | 0.89 | EDNRA (0.62) | EDNRAEDNRBLMNASMN1; SMN2MEN1 | |
| SCHEMBL8323818 | 0.89 | EDNRA (0.48) | EDNRAEDNRBLMNAEPHA2KDR | |
| SCHEMBL8327010 | 0.88 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8323904 | 0.88 | EDNRA (0.47) | EDNRAEDNRBLMNAEPHA2KDR | |
| SCHEMBL8324546 | 0.88 | EDNRA (0.47) | EDNRAEDNRBLMNAEPHA2KDR | |
| SCHEMBL8324693 | 0.88 | EDNRA (0.61) | EDNRAEDNRBLMNASMN1; SMN2KMT2A | |
| SCHEMBL8329894 | 0.88 | EDNRA (0.60) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |