Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324551 | 1.00 | LMNA (0.54) | LMNAUSP2KDM4EMEN1POLB | |
| SCHEMBL8319694 | 0.89 | PTGER4 (0.53) | LMNAKDM4EMEN1POLBKMT2A | |
| SCHEMBL8322341 | 0.89 | PTGER4 (0.53) | LMNAKDM4EMEN1POLBKMT2A | |
| SCHEMBL8319700 | 0.89 | PTGER4 (0.53) | LMNAKDM4EMEN1POLBKMT2A | |
| SCHEMBL8321448 | 0.88 | APP (0.58) | LMNAKDM4EPOLBMAPTHDAC8 | |
| SCHEMBL8321452 | 0.88 | APP (0.58) | LMNAKDM4EPOLBMAPTHDAC8 | |
| SCHEMBL8323623 | 0.86 | GCK (0.56) | LMNAKDM4EMEN1MAPTKMT2A | |
| SCHEMBL5431545 | 0.80 | LRRK2 (0.63) | LMNAUSP2KDM4EPOLBCCR5 | |
| SCHEMBL8327004 | 0.78 | PTGER4 (0.53) | KDM4EMAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL8322642 | 0.78 | PTGER4 (0.53) | KDM4EMAPTHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |