Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329544 | 0.76 | KMT2A (0.45) | CASRALDH1A1LMNAKDM4E | |
| SCHEMBL8328742 | 0.75 | MGAM (0.44) | CASRALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8327469 | 0.72 | HTT (0.42) | ALDH1A1KDM4EHPGD | |
| Bromide SCHEMBL8330896 | 0.71 | MAPT (0.40) | LMNA | |
| SCHEMBL8328067 | 0.68 | RXFP1 (0.45) | ALDH1A1LMNAHTR2AKDM4EHPGD | |
| SCHEMBL11616192 | 0.68 | FOLH1 (0.58) | FOLH1ALDH1A1SLC16A3KDM4EHPGD | |
| Bromide SCHEMBL8329933 | 0.68 | ALDH1A1 (0.34) | CASRALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL30365583 | 0.66 | FOLH1 (0.76) | FOLH1ALDH1A1SLC16A3KDM4EHPGD | |
| SCHEMBL70392 | 0.66 | FOLH1 (0.76) | FOLH1ALDH1A1SLC16A3KDM4EHPGD | |
| Bromide SCHEMBL8322724 | 0.66 | CASR (0.40) | CASRALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |