Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.61 |
| ▸ | EDNRB | P24530 | 4/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320816 | 0.92 | EDNRA (0.64) | EDNRAEDNRBFKBP1AALDH1A1KMT2A | |
| SCHEMBL8322054 | 0.91 | EDNRA (0.57) | EDNRAEDNRBALDH1A1LMNAMAPT | |
| SCHEMBL8323252 | 0.88 | EDNRA (0.59) | EDNRAEDNRBALDH1A1KMT2ALMNA | |
| SCHEMBL8326558 | 0.88 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL8328969 | 0.87 | EDNRA (0.64) | EDNRAEDNRBALDH1A1MAPK1KMT2A | |
| SCHEMBL8324941 | 0.81 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL8328310 | 0.81 | EDNRA (0.47) | EDNRAEDNRB | |
| SCHEMBL9092381 | 0.81 | EDNRA (0.58) | EDNRAEDNRB | |
| SCHEMBL8327017 | 0.81 | EDNRA (0.55) | EDNRAEDNRBLMNA | |
| SCHEMBL8323785 | 0.81 | EDNRA (0.51) | EDNRAEDNRBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |