Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19187554 | 0.83 | TDP1 (0.73) | SMN1; SMN2ALDH1A1TDP1MAPTMAPK1 | |
| SCHEMBL27976453 | 0.82 | AKR1C3 (0.85) | SMN1; SMN2ALDH1A1GAAHTTTDP1 | |
| SCHEMBL4182066 | 0.81 | L3MBTL1 (0.73) | SMN1; SMN2ALDH1A1GAAHTTMAPT | |
| SCHEMBL632352 | 0.81 | L3MBTL1 (0.73) | SMN1; SMN2ALDH1A1GAAHTTMAPT | |
| SCHEMBL12182367 | 0.80 | L3MBTL1 (0.68) | ALDH1A1GAAMAPTMAPK1L3MBTL1 | |
| SCHEMBL8365003 | 0.80 | L3MBTL1 (0.71) | SMN1; SMN2ALDH1A1GAAHTTTDP1 | |
| SCHEMBL19049426 | 0.80 | L3MBTL1 (0.71) | SMN1; SMN2ALDH1A1GAAHTTTDP1 | |
| SCHEMBL1663638 | 0.80 | TDP1 (0.73) | SMN1; SMN2ALDH1A1GAAHTTTDP1 | |
| SCHEMBL1423369 | 0.80 | L3MBTL1 (0.71) | SMN1; SMN2ALDH1A1GAAHTTTDP1 | |
| SCHEMBL28083193 | 0.80 | L3MBTL1 (0.71) | SMN1; SMN2ALDH1A1GAAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |