Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221118 | 0.80 | SMN1; SMN2 (0.43) | KMT2AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL7850234 | 0.80 | KDM4E (0.41) | KMT2AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL30206064 | 0.79 | KDM4E (0.43) | KMT2AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL3580632 | 0.79 | KDM4E (0.43) | KMT2AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL18770224 | 0.75 | METAP1 (0.42) | KMT2AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL25644287 | 0.75 | L3MBTL1 (0.42) | KMT2AKDM4EALDH1A1TSHRL3MBTL1 | |
| SCHEMBL24347805 | 0.73 | L3MBTL1 (0.41) | KMT2AKDM4EALDH1A1TSHRL3MBTL1 | |
| SCHEMBL19706550 | 0.73 | L3MBTL1 (0.41) | KMT2ATSHRL3MBTL1ALOX15NAPRT | |
| SCHEMBL11638793 | 0.73 | L3MBTL1 (0.41) | KMT2AKDM4EMAPTALDH1A1TSHR | |
| SCHEMBL29200836 | 0.73 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900799-A1 | Novel atropisomers of 2,3-disubstituted-(5,6)-heteroarylfused-pyrimidin-4-ones | Pfizer Products Inc. (US) | 1999-03-10 | — | — | EP | disclosed |