Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734324 | 0.85 | SSTR5 (0.44) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL6974761 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL7724896 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL8354087 | 0.83 | PDE4A (0.47) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| Hydrochloric Acid SCHEMBL7724907 | 0.83 | PDE4A (0.46) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL8325337 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL13350324 | 0.82 | PDE4A (0.46) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL7735162 | 0.82 | PDE5A (0.47) | PDE4APDE4BPDE4DPDE4CSSTR5 | |
| SCHEMBL7734051 | 0.80 | PDE4D (0.49) | PDE4APDE4BPDE4DPDE4C | |
| Hydrochloric Acid SCHEMBL7734781 | 0.79 | PDE4D (0.49) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |